When the Spanish arrived, there were perhaps about 20,000 Native Americans in south Florida. By 1763, when the English gained control of Florida, the native peoples had all but been wiped out through war, enslavement, or had European diseases.
Other native peoples from Alabama and Georgia moved into Florida in the early 18th century. They were of varied ancestry, but Europeans called them all "Creeks." In Florida, they were known as the Seminole and Miccosukee Indians. The Seminoles clashed with American settlers over land and over escaped slaves who found refuge among them. They resisted the government's efforts to move them to the Indian Territory west of the Mississippi. Between 1818 and 1858, three wars were fought between Seminoles and the United States government. By 1858, there were very few Seminoles remaining in Florida.
The area that was to become West Palm Beach was settled in the late 1870s and 1880s by a few hundred settlers who called the vicinity "Lake Worth Country." These settlers were a diverse community from different parts of the United States and the world. They included founding families such at the Potters and the Lainharts, who would go on to become leading members of the business community in the fledgling city.